Biolane is Effective for Osteoarthritis of the Knee


Gray, S. K, (SGC) and Croft, J. E. (Scientific Marine), Auckland, New Zealand

One of the most common presentations of osteoarthritis is in the knee joint also known as gonarthritis.  The knee joint takes a lot of stress.  Obesity and excessive weight on the knee joints is a common cause of osteoarthritis of the knee[2], and lifestyle factors such as high impact and repetitive sports or jobs can contribute to the development of osteoarthritis[3].  The degeneration of the knee joint tissue can also be a natural occurrence as people age due to regular wear and tear on these important joints over decade of use[4]. 

While this condition can have a significant impact on mobility and Quality of Life for the general public, for athletes and sportspeople it can have a serious impact on their ability to perform in their chosen sport and profession.[5]

Treatments for osteoarthritis of the knee can include anti-inflammatory drugs, chiropractic manipulation and invasive surgery. Having a non-invasive means of ameliorating the signs and symptoms of osteoarthritis of the knee is of major benefit for many sufferers.[6] 

Several studies have shown the benefit of Biolane as a treatment for osteoarthritis of the knee. 

Study 1

A 6 month double blind, randomized, placebo controlled human clinical trial demonstrated that Biolane statistically significantly improved the symptoms of gonoarthritis (arthritis of the knee).

There were 53 patients in this clinical trial with radiographically confirmed gonoarthritis with clinically stable pain for several weeks prior to entry to the study. 

The results showed that the Biolane group demonstrated overall effectiveness rated as “excellent” in 40% of cases and never “negative” whilst the placebo group demonstrated effectiveness rated as “negative” in 40% of cases and never “excellent”.[7]

Study 2

Another study sought to evaluate the efficacy of Biolane and Chiropractic Mobilisation in the Treatment of Osteoarthritis of the Knee Joint.  45 patients were treated either with Biolane, Chiropractic mobilization or a combination of both for 8 weeks.

The results showed that patients in the Biolane only arm and Biolane + Chiropractic mobilization arms showed statistically significant improvement in Flexion, Extension and Lateral Rotation and Cincinnati Knee Rating System Score (Joint function) compared with the patients in the chiropractic mobilization only arm.  The author concluded that Biolane and Biolane + chiropractic mobilization was more effective than chiropractic mobilization alone.[8]

Study 3

A retrospective study of 218 patients treated with Biolane for osteoarthritis of the knee was followed-up for two years. The severity of disease ranged from Stage I – Minimal Symptoms to Grade IV Severe Symptoms.  Mobility improved in 84%, and management was effective in 88% of the patients. 

The conclusion was that Biolane showed a satisfactory effect on Stages I ,II,and III patients with OA of the knee, particularly, when combined with a regular course of physical therapy and a short course of NSAIDS.  Biolane was effective in relieving pain and improving mobility[9].

Study 4

Another retrospective study of 345 patients – 297 of which had osteoarthritis of the knee, were treated and followed up for 1 year.  Biolane was shown to be very effective in the relief of pain and improvement of mobility for early and moderate osteoarthritis of the knee[10].

Study 5

More recently a study of 112 patients treated with Biolane for osteoarthritis of the knee, were followed up for one to three years.  There was improvement in motion in 74% of patients.  The authors concluded that Biolane is a valid and reliable option for the treatment of early osteoarthritis[11].

Of significance from these trials is that the age range of the patients in these trials spanned early adult (<30 years old) through to elderly (>75 years old).  This confirms that osteoarthritis of the knee is not just an old people’s disease and that Biolane is an effective treatment for knee osteoarthritis. 

Oxford University Hospitals, Oxford, UK


[1] Thor, F, et al, “A Modeling Framework to Estimate Patellofemoral Joint Cartilage Stress In Vivo”, Medicine & Science in Sports & Exercise, 12; 37(11):1924-30, 2005.

[2] Coggon D, et al, “Knee Osteoarthritis and Obesity”, International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity, 25(5):622-627. 2001.Find all citations by this author (default).Or filter your current search Find all citations in this journal (default).Or filter your current search

[3] Buckwalter JA, “”Sports, Joint Injury, and Posttraumatic Osteoarthritis”, J Orthop Sports Phys Ther, Oct;33(10):578-88, 2003.

[4] Anderson SA, Loeser RF., “Why is Osteoarthritis an Age-Related Disease?”,Best Pract Res Clin Rheumatol,  Feb;24(1):15-26, 2010.
[5] Wolf BR, Amendola A. “Impact of Osteoarthritis on Sports Careers”. Clin Sports Med,  Jan;24(1):187-98, 2005.

[6] McAlindon T.E, “OARSI Guidelines for the Non-Surgical Management of Knee

Osteoarthritis”, Osteoarthritis and Cartilage, 22 363-388, 2014.

[7] Audeval, B., Bouchacourt, P, “Double Blind, Placebo Controlled Study of the Mussel Perna Canaliculus (New Zealand Green-lipped mussel) in Gonoarthritis (Arthritis of the Knee)”, La Gazette Medicale, 93 (38), 1986.

[8] Hawkings, T, “The Effects of Chiropractic Mobilisation and Oral Administration of Seatone in the Treatment of Osteoarthritis of the Knee Joint”, PhD Thesis, 2002.

[9] Khalaf, Wae’l Abu, “Conservative Management of Early Knee Osteoarthrosis”, unpublished data on file Vitaco, 2003.

[10] Othman, Yousef, “Efficacy of Seatone in Osteoarthritis of the Knee”, unpublished data on file Vitaco, 2002.

[11] Khalaf, Wae’l Abu, “Conservative Management of  Early Knee Osteoarthrosis”, unpublished data on file Vitaco, 2009.

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